Reading
between
the lines.

Philosophy.

Roughly 60% of body weight is fluid. Around two-thirds of this is intracellular (within cells), approximately one quarter is interstitial (between cells), 8% or so is plasma (blood), and about 1% is transcellular.

Transcellular fluids are the specialized substances within defined compartments — such as the choroid plexus (cerebrospinal fluid), eye (vitreous humor), joints (synovial fluid), and the female reproductive tract (vaginal, cervical, uterine, oviductal, and follicular fluids). We study this overlooked 1%, alongside select interstitial fluids that bathe our cells.

Our primary focus is the uterine cavity, where maternal-embryo communication is orchestrated, in addition to the endometrial interstitium, where systemic endocrine and local epithelial-stromal juxtacrine and paracrine communication coordinates monthly endometrial regeneration.

Rather than studying cells in isolation, we center on the extracellular environments connecting them — interrogating these fluids to gain mechanistic insight into the communication networks that drive physiological processes and go awry in disease.

Most mechanics will tell you: check the fluids first. We took that advice seriously.